Genomic instability leads to cancer. Also genomic instability promotes diversity of the malignant cells within the tumour. DNA damage and chromosome segregation defects are the two major causes of gross instability. We aim to study both problems and their relationship with the life and death of the cell. We use the model organism Saccharomyces cerevisiae as well as tumour tissues to gain insights into the complexity of the maintenance of the integrity of the genome. We are also interested in genotoxic drugs and on how they can reshape the genome. We also test new drugs against yeasts and bacteria and try to uncover their mechanism(s) of action.
Grants
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Study of the nucleolar protein PICT1 as a possible marker in Renal Carcinoma and its correlation with histological grade, tumor aggressiveness, and expression of p53 variants and Klotho. 17/12/2018 - 31/12/2020. Fundación DISA. OA18/085. PI: Emiliano Matos.
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Prognostic biomarkers in locoregional melanoma: Study of the expression of immune checkpoint proteins. 01/01/2018 - 31/12/2019. Fundación Canaria de Investigación Sanitaria (FUNCANIS). PIFUN01/17. PI: Ricardo Fdez-Misa.
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Screening of natural and synthetic compounds in the Canary Islands for biopharmacological potential against neurodegenerative diseases. 01/04/2018 - 01/09/2020. Agencia Canaria de Investigación Innovación y Sociedad de la Información (ACIISI). ProID2017010167. PI: Félix Machín.
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Characterization of signalling and repair of DNA double strand breaks taking place in either telophase or an anaphase bridge. 01/01/2018 - 31/12/2021. Plan Nacional I+D+i "Retos de la Sociedad". BFU2017-83954-R. PI: Félix Machín.
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Short- and long-term consequences for the cell progeny of the presence of anaphase bridges due to genetic defects and chemical induction. 01/01/2016 - 31/12/2017. Plan Nacional I+D+i "Retos de la Sociedad". BFU2015-63902-R. PI: Félix Machín.
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Search for genetic defects and chemical agents that cause anaphase bridges and study of their consequences for the cell progeny. 01/01/2013 – 31/12/2015. Instituto de Salud Carlos III (Fondo de Investigación Sanitaria). PI12/00280. PI: Félix Machín.
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Improvement Of Biomedical Research And Innovation In The Canary Islands (IMBRAIN). 2012 - 2016. European Union. FP7-REGPOT-2012-2013-1-316137. PI: Rafael Alonso.
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Consequences of sister chromatid resolution failure on the life of the cell and search for resolution inhibitors. 01/01/2010 – 31/12/2012. Instituto de Salud Carlos III (Fondo de Investigación Sanitaria). PS09/00106. PI: Félix Machín.
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Carcinogenesis of multiple sporadic basocellular carcinoma. 01/03/2008 - 01/03/2010. Fundación Canaria para la Investigación y la Salud (FUNCIS). 06/24. PI: José Suárez.
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Genomic instability in the ribosomal DNA as a molecular marker in cancer. 01/03/2008 - 01/03/2010. Fundación Canaria para la Investigación y la Salud (FUNCIS). 06/21. PI: Félix Machín.
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Characterisation of sister chromatid nondisjunction during metaphase-anaphase transition and its prevalence in cancer. Possible clinical and therapeutical applications.01/12/2007 – 31/12/2009. Instituto de Salud Carlos III (Fondo de Investigación Sanitaria). PI06/1211. PI: Félix Machín.
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Characterisation of genetic factors involved in genomic stability of repetitive regions. Assessment of their contribution to genomic instability in Cancer and possible anti-tumour applications.15/12/2005 - 15/12/2007. Programa Ramón y Cajal (Ministerio de Educación y Ciencia). 1354. PI: Félix Machín.