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    2019​

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  • Ayra-Plasencia J, Machín F. DNA double-strand breaks in telophase lead to coalescence between segregated sister chromatid loci. 

​      Nat Commun. 2019 Jun 28;10(1):2862. doi: 10.1038/s41467-019-10742-8.

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    2018

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  • García-Luis J, Machín F. Fanconi Anaemia-Like Mph1 Helicase Backs up Rad54 and Rad5 to Circumvent Replication Stress-Driven Chromosome Bridges. Genes (Basel). 2018;9(11):558. doi:10.3390/genes9110558.

 

  • Anaissi-Afonso L, Oramas-Royo S, Ayra-Plasencia J, et al. Lawsone, Juglone, and β-Lapachone Derivatives with Enhanced Mitochondrial-Based Toxicity. ACS Chem Biol. June 2018. doi:10.1021/acschembio.8b00306.

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  • Matos-Perdomo E, Machín F. TORC1, stress and the nucleolus. Aging (Albany NY). 2018;10(1):1-2. doi:10.18632/aging.101456.

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  • Matos-Perdomo E, Machín F. The ribosomal DNA metaphase loop of Saccharomyces cerevisiae gets condensed upon heat stress in a Cdc14-independent TORC1-dependent manner. Cell Cycle. 2018;17(2):200-215. doi:10.1080/15384101.2017.1407890.

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    2017

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  • Oramas-Royo S, Pantoja KD, Amesty Á, et al. Synthesis and antibacterial activity of new symmetric polyoxygenated dibenzofurans.

      Eur J Med Chem. 2017;141:178-187. doi:10.1016/j.ejmech.2017.09.062.

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  • Ramos-Pérez C, Ayra-Plasencia J, Matos-Perdomo E, Lisby M, Brown GW, Machín F. Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in Saccharomyces cerevisiae. G3 (Bethesda). 2017;7(10):3379-3391. doi:10.1534/g3.117.300104.

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  • Quintana-Espinoza P, Martín-Acosta P, Amesty Á, et al. 5-Ethynylarylnaphthalimides as Antitumor Agents: Synthesis and Biological Evaluation. Bioorg Med Chem. 2017;25(6):1976-1983. doi:10.1016/j.bmc.2017.02.024.

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  • Hueso-Falcón I, Amesty Á, Anaissi-Afonso L, Lorenzo-Castrillejo I, Machín F, Estévez-Braun A. Synthesis and biological evaluation of naphthoquinone-coumarin conjugates as topoisomerase II inhibitors. Bioorg Med Chem Lett. 2017;27(3):484-489. doi: 10.1016/j.bmcl.2016.12.040.

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    2016

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  • Peña R, Martín P, Feresin GE, Tapia A, Machín F, Estévez-Braun A.J. Domino Synthesis of Embelin Derivatives with Antibacterial Activity. J Nat Prod. 2016;79(4):970-7. doi: 10.1021/acs.jnatprod.5b01038.

 

  • Machín F, Quevedo O, Ramos-Pérez C, García-Luis J. Cdc14 phosphatase: warning, no delay allowed for chromosome segregation!  

      Curr Genet. 2016;62(1):7-13. doi: 10.1007/s00294-015-0502-1.

   

    2015

 

  • Quevedo O, Ramos-Pérez C, Petes TD, Machín F. The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae. Genetics. 2015;200(3):755-69. doi: 10.1534/genetics.115.177626.

 

  • Casero C, Machín F, Méndez-Álvarez S, Demo M, Ravelo ÁG, Pérez-Hernández N, Joseph-Nathan P, Estévez-Braun A. Structure and Antimicrobial Activity of Phloroglucinol Derivatives from Achyrocline satureioides. J Nat Prod. 2015;78(1):93-102. doi: 10.1021/np500735f.

 

    2014 

 

  • García-Luis, J. and Machín, F. Mus81-Mms4 and Yen1 resolve a novel anaphase bridge formed by noncanonical Holliday junctions. 

      Nat Commun. 2014;5:5652 doi: 10.1038/ncomms6652 .

 

  • Ramos-Pérez C, Lorenzo-Castrillejo I, Quevedo O, García-Luis J, Matos-Perdomo E, Medina-Coello C, Estévez-Braun A, Machín F. Yeast cytotoxic sensitivity to the antitumour agent β-lapachone depends mainly on oxidative stress and is largely independent of microtubule- or topoisomerase-mediated DNA damage. Biochem Pharmacol. 2014;15;92(2):206-19. doi:10.1016/j.bcp.2014.09.006. 

 

  • Campos-Peña E, Martín-Nuñez E, Pulido-Reyes G, Martín-Padrón J, Caro-Carrillo E, Donate-Correa J, Lorenzo-Castrillejo I, Alcoba-Flórez J, Machín F,Méndez-Alvarez S. Multiplex PCR Assay for Identification of Six Different Staphylococcus spp. and Simultaneous Detection of Methicillin and Mupirocin Resistance. J Clin Microbiol. 52(7):2698-701. doi:10.1128/JCM.00918-14.

 

  • García-Luis J, Clemente-Blanco A, Aragón L, Machín F. Cdc14 targets the Holliday junction resolvase Yen1 to the nucleus in early anaphase. Cell Cycle. 2014;13(9):1392-9. doi: 10.4161/cc.28370.

     

     2013

 

  • Quintana-Espinoza P, García-Luis J, Amesty A, Martín-Rodríguez P, Lorenzo-Castrillejo I, Ravelo AG, Fernández-Pérez L, Machín F, Estévez-Braun A. Synthesis and study of antiproliferative, antitopoisomerase II, DNA-intercalating and DNA-damaging activities of arylnaphthalimides. (2013) Bioorg Med Chem. Nov 1;21(21):6484-95. doi: 10.1016/j.bmc.2013.08.039. Epub 2013 Aug 29. PMid:24054489

 

  • Peña R, Jiménez-Alonso S, Feresin G, Tapia A, Méndez-Alvarez S, Machín F, Ravelo ÁG, Estévez-Braun A. Multicomponent synthesis of antibacterial dihydropyridin and dihydropyran embelin derivatives. (2013) J Org Chem. Aug 16;78(16):7977-85. doi: 10.1021/jo401189x. Epub 2013 Jul 22. PMid:23841668

 

  • Casero C, Estévez-Braun A, Ravelo AG, Demo M, Méndez-Álvarez S, Machín F. Achyrofuran is an antibacterial agent capable of killing Methicillin-resistant Vancomycin-intermediate Staphylococcus aureus in the nanomolar range. (2013)  Phytomedicine. Jan 15;20(2):133-8. doi: 10.1016/j.phymed.2012.11.003. Epub 2012 Dec 5. PMid:23219042

 

     2012

 

  • Quinto-Alemany D, Canerina-Amaro A, Hernández-Abad LG, Machín F, Romesberg FE, Gil-Lamaignere C. Yeasts acquire resistance secondary to antifungal drug treatment by adaptive mutagenesis. (2012) PLoS One. ;7(7):e42279. doi: 10.1371/journal.pone.0042279. Epub 2012 Jul 31. PMid:22860105

 

  • Quevedo O, García-Luis J, Matos-Perdomo E, Aragón L, Machín F. Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2. (2012) PLoS Genet. Feb;8(2):e1002509

   

     2011

 

  • Quevedo O, García-Luis J, Lorenzo-Castrillejo I, Machín F. No role of homologous recombination in dealing with β-lapachone cytotoxicity in yeast. (2011) Chem Res Toxicol. Dec 19;24(12):2106-8. doi: 10.1021/tx2004618. Epub 2011 Nov 22.

 

     2009

 

  • Sperry J, Lorenzo-Castrillejo I, Brimble MA, Machín F. Pyranonaphthoquinone derivatives of eleutherin, ventiloquinone L, thysanone and nanaomycin A possessing a diverse topoisomerase II inhibition and cytotoxicity spectrum.(2009) Bioorg Med Chem. Oct 15;17(20):7131-7. doi: 10.1016/j.bmc.2009.08.064. Epub 2009 Sep 4.PMid:19783445

   

  • Clemente-Blanco A, Mayán-Santos M, Schneider DA, Machín F, Jarmuz A, Tschochner H, Aragón L. Cdc14 inhibits transcription by RNA polymerase I during anaphase. (2009) Nature. Mar 12;458(7235):219-22. doi: 10.1038/nature07652. Epub 2009 Jan 21.PMid:19158678

   

     2008

 

  • Jiménez-Alonso S, Orellana HC, Estévez-Braun A, Ravelo AG, Pérez-Sacau E, Machín F. Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors. (2008) J Med Chem. Nov 13;51(21):6761-72. doi: 10.1021/jm800499x. Epub 2008 Sep 25.PMid:18816045

   

      2007

 

  • Torres-Rosell J, De Piccoli G, Cordon-Preciado V, Farmer S, Jarmuz A, Machin F, Pasero P, Lisby M, Haber JE, Aragón L. Anaphase onset before complete DNA replication with intact checkpoint responses.(2007) Science. Mar 9;315(5817):1411-5.PMid:17347440

 

     2006

 

  • De Piccoli G, Cortes-Ledesma F, Ira G, Torres-Rosell J, Uhle S, Farmer S, Hwang JY, Machin F, Ceschia A, McAleenan A, Cordon-Preciado V, Clemente-Blanco A, Vilella-Mitjana F, Ullal P, Jarmuz A, Leitao B, Bressan D, Dotiwala F, Papusha A, Zhao X, Myung K, Haber JE, Aguilera A, Aragón L. Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.(2006) Nat Cell Biol. Sep;8(9):1032-4. Epub 2006 Aug 6.PMid:16892052

   

  • Machin F, Torres-Rosell J, De Piccoli G, Carballo JA, Cha RS, Jarmuz A, Aragon L. Transcription of ribosomal genes can cause nondisjunction. (2006) J Cell Biol. Jun 19;173(6):893-903. Epub 2006 Jun 12.PMid:16769819

 

  • Navarro FJ, Machín F, Martín Y, Siverio JM. Down-regulation of eukaryotic nitrate transporter by nitrogen-dependent ubiquitinylation. (2006) J Biol Chem. May 12;281(19):13268-74. Epub 2006 Mar 16.PMid:16543229

 

  • Clemente-Blanco A, González-Novo A, Machín F, Caballero-Lima D, Aragón L, Sánchez M, de Aldana CR, Jiménez J, Correa-Bordes J. The Cdc14p phosphatase affects late cell-cycle events and morphogenesis in Candida albicans. (2006) J Cell Sci. Mar 15;119(Pt 6):1130-43. Epub 2006 Feb 28.PMid:16507592

 

     2005

 

  • Torres-Rosell J, Machin F, Aragón L. Smc5-Smc6 complex preserves nucleolar integrity in S. cerevisiae. (2005) Cell Cycle. Jul;4(7):868-72. Epub 2005 Jul 5.PMid:15917663

 

  • Torres-Rosell J, Machín F, Farmer S, Jarmuz A, Eydmann T, Dalgaard JZ, Aragón L. SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. (2005) Nat Cell Biol. Apr;7(4):412-9. Epub 2005 Mar 27.PMid:15793567

   

  • Machin F, Torres-Rosell J, Jarmuz A, Aragon L. Spindle-independent condensation-mediated segregation of yeast ribosomal DNA in late anaphase. (2005) J Cell Biol. Jan 17;168(2):209-19.PMid:15657393

 

  • Torres-Rosell J, Machín F, Aragón L. Cdc14 and the temporal coordination between mitotic exit and chromosome segregation. (2005)  Cell Cycle. Jan;4(1):109-12. Epub Jan 10. Review.PMid:15611663

 

     2004

 

  • Torres-Rosell J, Machín F, Jarmuz A, Aragón L. Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network. (2004) Cell Cycle. Apr;3(4):496-502. Epub 2004 Apr 1.PMid:15004526

 

  • Machín F, Medina B, Navarro FJ, Pérez MD, Veenhuis M, Tejera P, Lorenzo H, Lancha A, Siverio JM. The role of Ynt1 in nitrate and nitrite transport in the yeast Hansenula polymorpha. (2004) Yeast. Feb;21(3):265-76.PMid:14968431

   

  • Machín F, Paschos K, Jarmuz A, Torres-Rosell J, Pade C, Aragón L. Condensin regulates rDNA silencing by modulating nucleolar Sir2p. (2004) Curr Biol. Jan 20;14(2):125-30.PMid:14738734

 

     2003

 

  • Navarro FJ, Perdomo G, Tejera P, Medina B, Machín F, Guillén RM, Lancha A, Siverio JM. The role of nitrate reductase in the regulation of the nitrate assimilation pathway in the yeast Hansenula polymorpha.(2003) FEMS Yeast Res.Nov;4(2):149-55.PMid:14613879

 

     2002

 

  • Perdomo G, Navarro FJ, Medina B, Machín F, Tejera P, Siverio JM. Tobacco Nia2 cDNA functionally complements a Hansenula polymorpha yeast mutant lacking nitrate reductase. A new expression system for the study of plant proteins involved in nitrate assimilation. (2002) Plant Mol Biol. Oct;50(3):405-13.PMid:12369617

 

  • Avila J, González C, Brito N, Machín F, Pérez MD, Siverio JM. A second Zn(II)(2)Cys(6) transcriptional factor encoded by the YNA2 gene is indispensable for the transcriptional activation of the genes involved in nitrate assimilation in the yeast Hansenula polymorpha.(2002) Yeast. Apr;19(6):537-44.PMid:11921102

 

     2001

 

  • Machín F, Perdomo G, Pérez MD, Brito N, Siverio JM. Evidence for multiple nitrate uptake systems in the yeast Hansenula polymorpha. (2001) FEMS Microbiol Lett. Jan 15;194(2):171-4.PMid:11164303

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